Journal article
Stromal lymphocytes are associated with upgrade of B3 breast lesions
T Kader, E Provenzano, MW Jayawardana, S Hendry, JM Pang, K Elder, DJ Byrne, L Tjoeka, HML Frazer, E House, SI Jayasinghe, H Keane, A Murugasu, N Rajan, IM Miligy, M Toss, AR Green, EA Rakha, SB Fox, GB Mann Show all
Breast Cancer Research | BMC | Published : 2024
Abstract
Various histopathological, clinical and imaging parameters have been evaluated to identify a subset of women diagnosed with lesions with uncertain malignant potential (B3 or BIRADS 3/4A lesions) who could safely be observed rather than being treated with surgical excision, with little impact on clinical practice. The primary reason for surgery is to rule out an upgrade to either ductal carcinoma in situ or invasive breast cancer, which occurs in up to 30% of patients. We hypothesised that the stromal immune microenvironment could indicate the presence of carcinoma associated with a ductal B3 lesion and that this could be detected in biopsies by counting lymphocytes as a predictive biomarker ..
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Awarded by University of Melbourne
Funding Acknowledgements
We thank A/P Prue Hill (St Vincent's Hospital, Melbourne) (retired) for the review of St Vincent's B3 cases and Maria Bisignano (Melbourne Health Pathology) for coordinating NWBS cases. We thank the Nottingham Health Science Biobank and Breast Cancer Now Tissue Bank for the provision of tissue samples.